AOD-9604
Metabolic ResearchCAS 221231-10-3
Available sizes: 5 mg
The lipolytic fragment of growth hormone
AOD-9604 is hGH(177-191) with an N-terminal tyrosine. Fragment studies of growth hormone in the 1970s and 80s indicated that effects on adipose tissue mapped to the C-terminal region, and could be separated from the growth-promoting activity of the whole hormone.
That separation is the compound's entire research rationale. It does not meaningfully bind the growth hormone receptor and is not reported to raise IGF-1, so observations made with it cannot be attributed to the somatotropic axis.
Research areas
Adipocyte lipolysis and lipogenesis in culture and in animal models
Beta-3 adrenergic receptor expression, a proposed mechanism
Structure-activity work on growth hormone fragments
Cartilage and joint models, a separate and smaller literature this compound also appears in
Human trial results have been mixed, and that is worth stating alongside the mechanistic rationale rather than after it.
Read alongside
Tesamorelin approaches adipose tissue through the intact somatotropic axis — the comparison between the two is precisely the question AOD-9604 was built to ask. IGF-1 LR3 is the mediator it avoids.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.