5-Amino-1MQ
Metabolic Research
Available sizes: 5 mg, 50 mg
An NNMT inhibitor
5-Amino-1-methylquinolinium is a small molecule, not a peptide. It inhibits nicotinamide N-methyltransferase, an enzyme expressed strongly in white adipose tissue and liver, and markedly upregulated in obese adipose tissue in animal models — an observation that is the origin of research interest in inhibiting it.
Two substrates, two consequences
NNMT transfers a methyl group from S-adenosylmethionine to nicotinamide. Both halves matter:
Nicotinamide is a precursor in the NAD+ salvage pathway. Methylating it removes it from that pathway, so NNMT activity competes with NAD+ regeneration.
SAM is the universal methyl donor for DNA, RNA and protein methylation. High NNMT activity consumes it, which connects the enzyme to epigenetic regulation.
Research areas follow directly: adipocyte metabolism and lipogenesis, NAD+ availability in adipose tissue, sirtuin activity downstream of NAD+, and methylation capacity as a separate axis.
Read alongside
NAD+ is the cofactor this mechanism converges on, and AICAR and SLU-PP-322 are the other small-molecule metabolic research compounds here.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.