ARA-290
Immunological Research
Available sizes: 10 mg
Erythropoietin with the erythropoiesis removed
Erythropoietin does two unrelated things. It drives red cell production through the classical EPO receptor homodimer, and it protects tissue under stress through a separate receptor complex — the EPO receptor paired with CD131, often called the innate repair receptor.
ARA-290 is an 11-residue peptide reproducing the helix B region of EPO that engages the second receptor and not the first. The design intent was explicit: obtain the tissue-protective signalling without raising haematocrit, which is the effect that limits EPO's use as a research and therapeutic tool.
Research areas
Small fibre neuropathy, the indication with the most substantial clinical trial data
Sarcoidosis, studied in parallel with the neuropathy work
Neuropathic pain models, where the tissue-protective mechanism is examined directly
Ischaemia-reperfusion injury, the classical setting for EPO's protective effects
Receptor pharmacology, using ARA-290 to establish which EPO effects belong to which receptor
Why the separation matters
A compound that isolates one arm of a hormone's activity is valuable beyond its own indications: it is an instrument for attributing effects. Much of the interest in ARA-290 is methodological — it lets the tissue-protective literature on EPO be tested without the confound of erythropoiesis.
Read alongside
Thymosin Alpha-1 is the other compound here with a formal clinical literature. For tissue repair through unrelated mechanisms, see BPC-157 and TB-500.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.