Thymosin Alpha-1
Immunological ResearchCAS 62304-98-7
Available sizes: 5 mg, 10 mg
A thymic peptide with a clinical record
Thymosin Alpha-1 is a 28-residue acetylated peptide first isolated from thymosin fraction 5, a thymic tissue extract. The thymus is where T lymphocytes mature, and the peptide's activity on T cell populations was what drew attention to it.
Unlike most compounds in this catalogue it has been through formal clinical development. It is approved under the name thymalfasin in a number of countries, which means its literature includes controlled trial data rather than only preclinical work.
Mechanism and research areas
The mechanism most reported is agonism at Toll-like receptors — particularly TLR9 and TLR2 — on dendritic cells, which influences how those cells present antigen and therefore how T cells differentiate. It is an immune modulator rather than an immune stimulant, and the distinction matters in the literature.
Chronic hepatitis B and C, the indications with the largest trial literature
Sepsis, where immune dysregulation rather than deficiency is the studied problem
Vaccine adjuvant research, particularly in populations that respond poorly
T cell maturation and differentiation in culture
Immunosenescence — age-related decline in adaptive immune function
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.