Epithalon
Cellular Longevity ResearchCAS 307297-39-8
Available sizes: 10 mg, 50 mg
A four-residue pineal peptide
Epithalon (also Epitalon or Epithalone) is Ala-Glu-Asp-Gly, synthesised as the minimal active sequence of epithalamin — a pineal extract developed by Vladimir Khavinson's group. It belongs to the same bioregulator class as the tissue-derived preparations, but unlike those it is a defined synthetic tetrapeptide rather than an extract.
The telomerase claim, stated precisely
The published finding is that Epithalon induces telomerase activity in human somatic cells in culture, permitting additional population doublings. Telomerase is normally silent in somatic cells, so an agent that switches it on would be genuinely notable.
Two things are worth stating alongside it. Most of this work originates from the group that developed the compound, and independent replication is limited. And telomerase induction is not uncomplicated even in principle — it is a hallmark of cancer cells as well as of extended replicative capacity, which is itself an active research question rather than an objection.
Telomerase activity and telomere length in cultured human fibroblasts
Pineal function and melatonin rhythm regulation with age
Antioxidant and lipid peroxidation measures
Lifespan studies in rodents and invertebrate models
Gene expression, the proposed mechanism common to the bioregulator class
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.