GHRP-6
Growth Factor ResearchCAS 87616-84-0
Available sizes: 5 mg, 10 mg
A receptor ligand that arrived before its receptor
GHRP-6 is historically important. It was developed from met-enkephalin analogues in the 1980s and shown to release growth hormone through a mechanism distinct from GHRH — which implied an unidentified receptor with an unidentified endogenous ligand. That receptor was later characterised as GHS-R1a, and the search for its natural ligand led to the discovery of ghrelin in 1999.
A synthetic compound leading to the discovery of a hormone is an unusual sequence of events, and it is why GHRP-6 appears in the historical sections of this literature as often as in the methods.
The appetite literature
GHRP-6 produces pronounced appetite stimulation, and that effect — a liability if growth hormone is the subject — is exactly what makes it useful for studying hunger signalling:
Appetite and food intake regulation via GHS-R1a
Ghrelin receptor pharmacology, as the historical reference ligand
Gastric motility and emptying
Comparative selectivity studies across the secretagogue class
Read alongside
GHRP-2 and Ipamorelin complete the selectivity series. For appetite regulation through a different receptor family, see Melanotan II at MC4R.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.