Ipamorelin
Growth Factor ResearchCAS 170851-70-4
Available sizes: 5 mg, 10 mg
A selective ghrelin receptor agonist
Ipamorelin is a five-residue synthetic peptide acting at GHS-R1a. Because that receptor is distinct from the GHRH receptor, the two classes can be stimulated independently — which is the basis of a large part of this field's experimental design.
It came out of a development programme explicitly aimed at selectivity, after the first-generation secretagogues proved too promiscuous to be useful as instruments.
Selectivity as the research property
An agonist that also raises cortisol and prolactin makes an experiment hard to interpret: any downstream observation may belong to one of several hormones. Ipamorelin's reported profile — growth hormone release with comparatively little effect on cortisol, prolactin or appetite — is what makes it a cleaner instrument than its predecessors.
Somatotropic axis stimulation without adrenal or lactotroph confounds
Dual-pathway studies alongside GHRH analogues
Ghrelin receptor pharmacology, using a selective agonist as reference
Gastric motility, where GHS-R1a has a separate and well-established role
Read alongside
GHRP-2 and GHRP-6 are the earlier, less selective secretagogues and the direct comparators. CJC-1295 + Ipamorelin is the dual-receptor preparation.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.