Sermorelin Acetate
Growth Factor ResearchCAS 86168-78-7
Available sizes: 5 mg, 10 mg
GHRH(1-29), the minimal active fragment
Growth hormone releasing hormone is 44 residues long. Sermorelin is the first 29 of them, and fragment studies established that this is the minimum needed for full agonist activity at the GHRH receptor on pituitary somatotrophs. The remaining 15 residues contribute nothing to binding.
It is degraded quickly, principally by DPP-4 cleaving the N-terminus, giving a half-life measured in minutes.
Why a short half-life is sometimes the requirement
Growth hormone is released in pulses, and the pattern carries information the axis responds to differently from a sustained signal. A short-acting analogue reproduces a pulse; a long-acting one does not. Experiments concerned with pulsatility, with receptor desensitisation, or with the shape of a secretory episode generally need the short-acting compound.
Pituitary responsiveness testing, where a discrete stimulus is required
Pulsatility and feedback studies on the somatotropic axis
Comparative work against longer-acting GHRH analogues
Ageing research, where GHRH responsiveness is a measured variable
Read alongside
CJC-1295 is the long-acting GHRH analogue and the standard comparator; Tesamorelin the stabilised clinical one. The secretagogues Ipamorelin, GHRP-2 and GHRP-6 reach the same axis through a different receptor.
Documentation and verification
Certificates of Analysis are published for tested products and batches. A certificate is a batch-specific record: it reports what was measured, by which method, on a stated date, against a batch identifier. It is evidence about the sample analysed at the time of analysis, and it is silent on attributes it does not list and on what has happened to the material since.
The batch number is the field that connects the document to a physical vial. Where the identifier on a vial does not appear on a certificate, the certificate does not describe that vial, however thorough the analysis behind it was. Batch records can be searched directly, and the guides below explain what each field establishes and what it does not.
- Verify a batchSearch a batch number for the certificate records published against it.
- How to read a certificate of analysisWhat each field reports, and the limits of what a certificate can establish.
- Certificate, specification and safety data sheetThree documents that answer three different questions.
- Storage and handlingWhat defined storage conditions mean, and why cold slows degradation.
- Batch numbers and traceabilityHow an identifier ties material to the analysis describing it.
Supplied for laboratory research use only. Not for human or veterinary use.